Which treatment has the most evidence supporting its effectiveness for warts?

The most evidence supporting the effectiveness of a treatment for warts is found in the use of over-the-counter salicylic acid. This topical treatment works by gradually peeling away the wart tissue. It is commonly recommended because it is easily accessible, user-friendly, and can be applied at home. Salicylic acid breaks down the protein (keratin) that makes up the wart and the thick layer of dead skin surrounding it, leading to effective wart removal over time.

More extensive clinical studies have shown that salicylic acid is well-tolerated and has consistent efficacy, making it a first-line treatment option for various types of warts, particularly common and plantar warts. Its robust data from trials supports its recommendation in pediatric and adult populations.

In comparison, while freezing warts with liquid nitrogen can also be effective, it is often performed in a clinical setting and its efficacy can be variable based on individual cases. Laser therapy and electrosurgery are typically reserved for more resistant or problematic warts and have less routine evidence supporting their use for common warts when compared to salicylic acid.